Wanderers went down 2-1 to MK Dons in the group stage of the Papa John's Trophy - a result that guarantees their exit from the competition.
MK opened the scoring early on through Hiram Boateng only for Brandon Hanlan to equalise soon after, but a game of few chances was settled in the second period by Zak Jules.
Two much-changed but strong line-ups took to the field with Wanderers including the likes of Joe Jacobson, Jordan Obita and David Wheeler in their starting XI, while youngsters Connor Parsons, Olly Pendlebury and Adam Przybek were given a chance to shine.
However it was the Dons who struck first, inside five minutes, when Mo Eisa was freed down the right wing and delivered an inch-perfect low cross for Hiram Boateng, who tucked home with ease.
But the scores were level just three minutes later, with almost a replica of the opening goal as Parsons latched on to a through-ball down the left and whipped in a ball for Brandon Hanlan to convert from six yards.
The action swung back to the other end, where Przybek denied Eisa's downward header with an excellent save away to his right, before his opposite number Franco Ravizzoli made a hash of a clearance, with Dominic Gape winning back possession and the chance ultimately fell to Anis Mehmeti, whose low goalbound shot was cleared for a corner.
Wanderers came close on 30 minutes, when Jacobson's corner was tipped on by Ravizzoli and Obita could only hammer over the bar on the stretch.
But that was the final chance of a first half that started with such promise, and ended with a whimper, with the scores level.
Hanlan had the first chance of the second half, striking wide of the far post from a narrow angle, and then David Wheeler's header from a corner took a nick and flashed over the bar.
Wheeler was booked for a foul on Josh Martin before MK swapped Mo Eisa with Charlie Brown, and they restored their lead with 62 minutes played as Zak Jules peeled off round the back from a free-kick and sidefooted home first time.
Another MK change arrived when Peter Kiosk entered the fray soon after, and Wycombe brought Tjay de Barr into the attack as Brandon Hanlan made way.
Curtis Thompson was introduced in midfield just as the rain began to hammer down with eight minutes remaining, and the Blues looked to apply pressure with Jordan Obita crossing invitingly for de Barr, whose headed went over the top.
Then de Barr was just unable to make contact with Wheeler's knockdown as the clock ticked towards 90, but unlike Saturday there was to be no stoppage time drama as Blues bowed out of the competition with one group stage game still to play.