Wanderers slipped to a 1-0 defeat to Stevenage in their opening group stage match in the Leasing.com Trophy on Tuesday night.
Jason Cowley's early header was enough to separate the sides on a night where an unusually subdued Wycombe outfit failed to threaten their League 2 visitors.
Gareth Ainsworth named an experimental side, with Joe Jacobson at centre-half, while Cameron Yates and Jacob Gardiner-Smith made their Chairboys debuts, Sido Jombati returned in defence, and Rolando Aarons and Josh Parker came into the attack.
Wycombe gradually got the grips with their unfamiliar setup, with Aarons looking the likeliest outlet for sparking a comeback, but Boro keeper Paul Farman was virtually untested, though Nnamdi Ofoborh did excellently to carve out a chance to deliver a low cross-shot across the face of goal, with no blue shirt able to convert.
A painfully stop-start half came to an end with no further action, but Boro were the sharper at the start of the second period, with Cowley snatching a chance wide from 12 yards, before the biggest cheer yet from the home fans came for Adam El-Abd, who came on as a sub for Stevenage on 50 minutes – his first appearance back at Adams Park since leaving Wycombe at the start of September.
Then came a goalmouth scramble where Curtis Thompson, Ofoborh and Yates all did well to prevent Boro from squeezing the ball over the line, before Wanderers made a double change as Dominic Gape and David Wheeler replaced Thompson and Aarons.
Joe Jacobson planted a header over the bar from a free-kick, and the final throw of the dice came with the introduction of Adebayo Akinfenwa, who took Scott Kashket’s place in the attack for the final 20 minutes.
Kelland Watts stung the palms of Yates with a fierce drive from distance, and Boro then withdrew their goalscorer Cowley as Paul Taylor came into the attack.
Wheeler had a header cleared off the line before Ofoborh blasted over the rebound in the final minute, but Ainsworth's men now return their focus to the league and the visit of Sunderland to Adams Park in 11 days' time.