David Wheeler and Matt Bloomfield were on target as Wanderers recorded a sixth successive clean sheet to move seven points clear at the top of League 1.
Anthony Stewart laid on the assist on his 200th Wycombe appearance for Wheeler to fire Wanderers in front, and Bloomfield sealed the win with a late strike to kill off the Brewers' hopes of a comeback.
The visitors arrived late at Adams Park, not reaching their changing room until 2.20pm, though Wanderers hadn’t played a game in two-and-a-half weeks, prompting an interesting spectacle to ascertain which of the two sides might enjoy the more prosperous start to the game.
Matt Bloomfield grew into the game at the heart of every Wycombe attack, driving from deep, and his low shot on 24 minutes was goalbound before being blocked behind for a corner, before the opening goal arrived from the resulting set-piece.
Joe Jacobson’s corner found its way through to Anthony Stewart the back post, and his rocket of a cross-shot was expertly turned home by David Wheeler with a first-time finish.
The game entered a lull, though David Templeton went close with a low placed shot from distance which was well watched wide by Ryan Allsop, and then Scott Fraser side-footed over from Colin Daniel’s cross.
Bloomfield hooked an effort on target as half-time drew near, while Curtis Thompson was booked for a foul, with Sido Jombati following suit before making a brave block to thwart the Brewers’ low cross before the whistle blew.
With no changes at the break, Burton came close to a leveller on 50 minutes when Stephen Quinn lashed wide from the edge of a box after a corner was half-cleared, and Joe Jacobson attempted a curling free-kick from 25 yards which missed the target.
Gareth Ainsworth made a double change on 65 minutes, with Scott Kashket and Adebayo Akinfenwa replacing Rolando Aarons and Alex Samuel, before Colin Daniel planted a header over the bar when unmarked 15 yards out.
The Brewers made a tactical switch on 70, moving their record-EFL goalscorer Lucas Akins up front as John Brayford came on in defence, with David Templeton making way. Soon after, Reece Hutchinson swapped with Colin Daniel at left-back.
Jake Buxton saw yellow for a captain-on-captain foul on Bloomfield, with Akinfenwa glancing a header on target from the resulting free-kick, but Kieran O’Hara held comfortably.
Alex Pattison replaced the already-booked Thompson on 80 minutes, and almost immediately Scott Kashket went close with a right-footed rocket which flew just past the post from the edge of the box.
Burton’s final change saw Oliver Sarkic replace Joe Sbarra,
There was a scare when Hutchinson’s low cross seemed destined for Lucas Akins, but Darius Charles dived in gallantly to steer it to safety, but all nerves were eased when Matt Bloomfield crashed home the second to spark euphoric celebrations.
Alex Pattison stayed onside and his cross was cleared to the Wycombe number 10, who stroked home his first of the season to ensure Wanderers will have a Christmas number 1.
Wycombe: Allsop, Jombati, Jacobson, Stewart, Charles, Thompson (Pattison 80), Ofoborh, Bloomfield, Wheeler, Aarons (Kashket 65), Samuel (Akinfenwa 65).
Unused subs: Yates, Phillips, Smyth, Freeman.
Burton: O’Hara, Akins, Daniel (Hutchinson 75), Buxton, Nartey, Quinn, Wallace, Fraser, Sbarra (Sarkic 82), Templeton (Brayford 70), Boyce.
Unused subs: Garrett, Anderson, Beardsley, Vale.
Attendance: 5,448 (186 away)