Scott Kashket struck early on to secure three points for the Chairboys on their last visit to Cheltenham in December 2016.
The first chance of the game brought about its only goal and there was more than an air of inevitability about it with Scott Kashket drilling home his 13th strike of the season, collecting Adebayo Akinfenwa's lay-off with the most crisp of shots into the bottom corner.
Wanderers had to survive a late onslaught from the hosts, but defensive heroics saw Gareth Ainsworth's men over the line.
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The advance allocation of tickets (450) for Saturday's game at Cheltenham are now sold out, but supporters can pay on the day at no extra cost (more than 500 available).