Ahead of the big game this Saturday, we take a look back at what happened when Cambridge last came to town in September 2015.
Adams Park | Sky Bet League Two
It was a particularly quiet start to the game with little action in front of goal - just a few shots off target for both sides in the early stages.
Sam Beasant, the substitute goalkeeper, immediately faced his first task; to try was to try and stop Garry Thompson's penalty, which he did, guessing correctly to dive down to his right to deny the spot-kick.
Wycombe needed to make the one-man advantage count and take the lead, which nearly happened through three big chances for the hosts within a matter of minutes. Firstly, Luke O'Nien tried his luck with a first-time shot from 35 yards which was inches away from finding the near top corner. Harriman's cross from the right bounced back off the crossbar but Marcus Bean's header on the rebound was straight at Beasant in goal. Bean had another glorious opportunity when his side-foot shot from close range hit the upright.
Cambridge United's resilient defence finally broke, no more than eight minutes later, when Michael Harriman hit a beauty, off the underside of the bar and in from outside the box with just 20 minutes left to play.
Gozie Ugwu could well have sealed the victory with a second goal in stoppage time when a long ball up field was brought down by him and he powered past defender Greg Taylor, but he couldn't quite find the finish after going through on goal and was denied by Beasant.
The win meant that Wycombe had won 8 out of 9 home matches against Cambridge United in all competitions - Let's hope it's 9 out of 10 by end of play on Saturday.