Report: Wycombe 1-2 CarlisleCarlisle came from behind to secure all three points at Adams Park after Adebayo Akinfenwa had headed the Chairboys into an early lead.
Jamie Proctor and Reggie Lambe were on target for Keith Curle's men with all three goals coming in the first half, as Wanderers were unable to force an equaliser despite sustained spells of pressure.
Gareth Ainsworth welcomed Paris Cowan-Hall into the starting line-up following a spell on the sidelines through injury, while Michael Harriman made his 100th appearance for the club and Sam Saunders also returned to the fold.
Wycombe were ahead inside three minutes when Akinfenwa headed home Anthony Stewart's cross following a corner, and the hosts looked good value for their lead, combining exciting wing play through Cowan-Hall and Alex Jakubiak with the effectiveness of crosses into the head of Akinfenwa.
But third-placed Carlisle levelled on 10 minutes when Proctor was afforded too much space outside the area to control a pass from the left and pick his spot into the bottom corner.
Back came the Wanderers, with Luke O'Nien forcing a save from Mark Gillespie before Will De Havilland's flick from Joe Jacobson's pinpoint corner was blocked at point blank range.
But then came the sucker punch, when a long punt forward from Carlisle was met by Reggie Lambe who stole in to poke home past the onrushing Jamal Blackman, giving the Blues an uphill struggle to get back into the game.
They came close when Gillespie tipped Sam Saunders' fierce shot around the post and Jakubiak was denied a penalty when he went down under a tangle of legs in the area, before Saunders fired wide with the keeper beaten.
United were able to calm the storm in the early stages of the second period, before Akinfenwa struck the inside of the post with a smart header from Blackman's long free-kick into the box.
Then Jakubiak saw his powerful shot bounce back off the keeper with a low drive from distance, and Cowan-Hall lofted a shot wide of the post after the keeper rushed to close down the chance following Akinfenwa's through-ball.
Chances kept coming with Jakubiak drilling over when well placed before substitute Matt Bloomfield bent an effort agonisingly wide from 20 yards after collecting a loose ball.
Carlisle boss Keith Curle was sent to the stands in the closing moments but his side did enough to keep the Wanderers at bay during stoppage time, and now Ainsworth's men will look to get back on track at the home of old foes Colchester on Tuesday night.