Wycombe succumbed to a 4-1 defeat to a strong Danny Hylton inspired Luton side at Kenilworth Road.
The former Oxford man hit a treble, and Jordan Cook scored the other as the home side picked up all three points.
Matt Bloomfield had appeared to have given Wanderers hope as he struck to make it 2-1, and Jamal Blackman saved a first half penalty but the Hatters’ pressure told as they scored two late goals to secure the win.
Gareth Ainsworth kept an unchanged side to the one that ran out 3-0 winners at Northampton in the Checkatrade Trophy on Tuesday night, and introduced Scott Kashket and Dominic Gape to the substitutes’ bench having signed on Deadline Day.
The home side started brightly, with full backs Stephen O’Donnell and Danny Potts providing the biggest attacking threat for Luton.
O’Donnell had the first effort of the game on 8 minutes, getting in behind Sido Jombati to shoot goalwards from a tight angle but Jamal Blackman was equal to it.
The opening goal was shortly to follow as Pelly-Ruddock Mpanzu showed a great bit of skill to beat Matt Bloomfield on the right wing, before firing a dangerous low cross which Danny Hylton flicked past Blackman at the near post.
Luton continued on the front foot and Jordan Cook should have made it two as he bore down on Blackman’s goal from an Mpanzu through ball, but his chipped effort was nowhere near high enough to get it over the on-loan Chelsea stopper.
A last ditch Michael Harriman challenge prevented Cameron McGeehan from a simple tap in after Blackman parried Mpanzu’s effort, with the Hatters man complaining he was fouled by Harriman and getting a yellow card for his protests. But McGeehan wouldn’t have to wait long for the the penalty chance he had been asking for as McGinn brought down Cook in the area on 28.
The Chairboys protested it was outside the area but referee Graham Scott pointed to the spot. McGeehan stepped up but Blackman dived low to his right to keep out his tame effort and keep the Chairboys in the game.
Heavy rain began to fall and it appeared Wycombe had weathered the Hatters storm as they gained more of a foothold in the game. Bloomfield tested Luton keeper Christian Walton who tipped his low effort wide and Anthony Stewart headed wide from the resulting corner.
It was 1-0 at the break but the home side came out for the second half on the front foot, with only a heroic goal line stop from Sido Jombati preventing Luton from doubling their lead inside the first five minutes of the second half.
But Luton were to find the second goal on 56 as Hylton was on the mark again to tap home after Blackman parried McGeehan’s initial effort, with the striker grabbing his second goal of the game.
That goal seemed to breathe life into Wycombe as they came forward and pulled a goal back through Matt Bloomfield on 65. The midfielder made a surging run and got on the end of Nick Freeman’s flick to calmly slot past Walton and give Wanderers a lifeline.
The introduction of Dominic Gape for his debut, Adebayo Akinfenwa and Garry Thompson gave even more impetus to the Wycombe attack as Luton moved deeper into their own half. Thompson had two quick fire efforts which Walton firstly held then tipped wide, and Gape harried the Hatters players, breaking up play and launching attacks.
Luton were content to play on the break and McGeehan was denied once again by Blackman, and despite Wycombe pressure Luton sealed the game in the 88th minute as Danny Hylton sealed his hattrick from the penalty spot.
The forward was felled under a soft challenge from De Havilland and picked himself up to send Blackman the wrong way, and it was four for the home side two minutes later as Jordan Cork finished off a swift counter attack from a Wycombe corner, neatly finishing under Blackman.
Wycombe: Blackman, Jombati, Harriman, Stewart, De Havilland, McGinn (Gape 53), Rowe, Bloomfield, Freeman (Thompson 72), Hayes, Southwell (Akinfenwa 72)
Unused subs: Richardson, Pierre, Wood, Kashket
Luton: Walton, O’Donnell, Potts, Mullins, Cuthbert, Cook, Mpanzu (Smith 68), Lee, McGeehan, Marriott (Vassell 82), Hylton (Famewo 90)
Unused subs: King, Gray, Gilliead, Justin
Attendance: 8,097 (Away: 530)