We pick out nine key storylines ahead of the Sky Bet League 2 clash at Adams Park on Saturday (k.o. 3pm).The great eight?
How do you follow the 'magnificent seven'? By equalling the club record of consecutive wins since entering the EFL 23 years ago. That's the opportunity that lies in wait for the Chairboys, who racked up eight back-to-back victories in 2006, and could match that feat with three points against the O's.
Not that one... we'll come to Scott Kashket later. Matt Bloomfield has played three home games against Orient in his career, and scored in each one. The midfielder is enjoying his best ever season in front of goal, netting four times already, and could be worth a punt to continue his 100% record against the Londoners.
Wanderers are unbeaten in their final home game before Christmas in this millennium; the quirky sequence stretches way back to 1999 when Millwall left Adams Park with all three points, but since then, the Chairboys have always sent their home fans into Christmas with a spring in their step. The 4-1 win against Southend and 2-1 success over Oxford in the past two years have been particular highlights during that trend.
If Orient are awarded a spot-kick on Saturday then expect left-back Callum Kennedy to throw his hat into the ring to take it. After all, he was all lined up to take AFC Wimbledon's penalty in the dying stages of the League 2 play-off final against Plymouth in May, only to have the ball taken off him by Adebayo Akinfenwa, who was keen to end his spell with the club with a famous goal at Wembley. The Beast dispatched the penalty and the rest was history, as he put out an appeal for a manager to sign him, and Gareth Ainsworth duly obliged in the summer.
Beast mode off
Sadly Chairboys fans will be deprived of the opportunity to watch Akinfenwa in action on Saturday following his red card at Notts County. He serves a one-match ban but will return for the Boxing Day trip to Plymouth. His absence provides an opportunity for somebody else, which could be Paul Hayes if he's recovered from injury in time, or perhaps Garry Thompson, who hit two goals in the Checkatrade Trophy win at Millwall.
Point to prove
In August, Orient decided Scott Kashket had no future at the club, having only made three starts and being given little opportunity to show his potential. Gareth Ainsworth took a punt and signed the striker on a short-term deal, which was later extended following a superb run of form which now stands at 11 goals in 10 games. He meets his former employers for the first time on Saturday.
New manager effect?
Wanderers seem to always face a side enjoying a resurgence under a new manager, and on Saturday they meet an Orient side who finally ended their winless run at home, earning a 1-0 win against Accrington. Former youth coach Andy Edwards has been given the first-team job on a permanent basis, becoming Orient's eighth manager in the same period that Gareth Ainsworth has held the post at Wycombe. Last time they met was Kevin Nolan's first game in charge of the O's, but he, Andy Hessenthaler and Alberto Cavasin have been and gone in the 11 months that have passed.
Martin Brennan returns to Adams Park as Orient's goalkeeping coach; he held the same role at Wycombe several years ago, initially brought to the club by Peter Taylor.
Man in the middle
Rob Lewis takes charge of just his third game this season, having made his return from an absence in the Checkatrade Trophy earlier this month. He brandished a red card to Carlisle's Luke Joyce on his last visit to Adams Park last season, but hasn't officiated an Orient game since 2012.