Wanderers will play at home to Fulham in the first round of the Capital One Cup, to be played in the week commencing 10th August.The tie will bring back memories of Wycombe's run to the semi-final of the competition in 2006, when goals from Jermaine Easter and Tommy Mooney earned a famous victory at Craven Cottage.
Fulham's last visit to Adams Park was for a pre-season friendly in 2012 when Mladen Petric, Bryan Ruiz and Steve Sidwell found the net in a 3-0 away win.
Gareth Ainsworth said: "It's a fantastic tie for the club and a great chance to test ourselves against Championship opposition.
"It was a similar tie last year when we played at Millwall and I thought our performance that night was excellent, and set the standard for the season ahead."
Ticket details will be announced in due course.