The former QPR man curled a second-half free-kick into the far corner to give his side the advantage and they were handed an extra boost moments later when United midfielder Cameron McGeehan kicked out at Matt Ingram, earning a red card.
Cambridge still had chances to claim a point late on but the Blues' defence stood firm, notching up a 12th clean sheet of the season on a day when the team's unbeaten run stretched to a dozen.
Gareth Ainsworth made two changes to his starting line-up as Matt Bloomfield and Aaron Holloway replaced Peter Murphy and Matt McClure, who both dropped to the subs’ bench.
Wycombe started the brightest and saw Fred Onyedinma skip away down the right wing in the first minute before his low cross was cleared, and a succession of early corners looked to unsettle the home side’s defence.
Aaron Holloway headed one of those deliveries over the bar before United grew into the game and saw Robbie Simpson’s near-post shot saved by Matt Ingram, and Holloway came close at the other end when his header from a well-measured Hogan Ephraim cross bounced just wide.
Simpson was the Us’ biggest goal threat and his low shot from outside the box was deflected onto the post before the same player saw a shot blocked in the area after Ryan Donaldson found space and picked him out.
The half ended goalless as the clock ticked past four hours since the ball found the net at either end in a Wanderers fixture, but that particular deadlock was broken seven minutes into the second period when Hogan Ephraim curled home a beauty of a free-kick to register his first goal of the season.
Michael Nelson had fouled Holloway on the corner of the area and Ephraim delivered a ball into the 'corridor of uncertainty', meaning keeper Chris Dunn's dive was in vain as it flew past him and into the net.
Cambridge forced a corner at the other end straightaway but while players congregated waiting for the delivery, Cameron McGeehan was adjudged to have kicked out at Matt Ingram, giving referee Andy Davies no option but to brandish the red card.
In truth, it didn't change the pattern of the game as Cambridge continued to apply pressure to the visiting backline, and sub Sullay Kaikai saw a low shot saved by Ingram before Jordan Slew wastefully fired wide at the near post after a teasing cross from the right.
Fred Onyedinma almost made the points safe when he flashed an effort just wide, before Ingram saved Ryan Donaldson's free-kick with ease and the same player headed wide from Richard Tait's stoppage time cross.
The final whistle sounded to signal a fine away win which sees the Blues rise to second in the table with 17 games remaining.