Wycombe will meet last year's finalists Aston Villa in the third round of the Emirates FA Cup.
Speaking moments after the draw was made on Monday night, manager Gareth Ainsworth said: "I'm really happy with the draw. The boys deserve their chance to have a shot at Premier League opposition and I'm sure it'll be a fantastic occasion at Adams Park."
The tie will be played at Adams Park on the weekend of Saturday 9th January 2016, with the potential for the game to be moved for television coverage.
The two sides last met in a friendly in 2013 which finished 2-2 at Adams Park, while the two competitive meetings have ended with sizeable victories for the Premier League side - they won 8-3 in 2005 and 5-0 in 2003, both in the League Cup.
Full details and ticket information will be announced in due course.