Second-half goals from Josh Scowen and Sam Wood kept Blues at the top of League 2.
Wanderers were able to celebrate their first ever Football League win against AFC Wimbledon with a confident, stylish and ultimately comfortable success over the Wombles, reducing the visitors to one chance of any note and silencing prolific scorers Matt Tubbs and Bayo Akinfenwa.
Josh Scowen opened the scoring with a tidy finish after the ball found him in space on the edge of the box, and the points were secure when Sam Wood nodded home Steven Craig's shot from close range.
The Blues were handed a huge boost before kick-off with the news that Aaron Pierre was fit to start after suffering a head injury last weekend, with Danny Rowe returning on loan from Rotherham to provide cover on the bench.
After a quiet opening, Joe Jacobson had the first effort of the game after 14 minutes but his long-range free-kick whistled a yard or two wide after a foul on Sam Wood.
Josh Scowen tested the handling of keeper James Shea with a powerful drive from distance, but the former Arsenal youngster was equal to it.
Attention then turned to the man in the middle who dished out four yellow cards in quick succession, adding a sting to the game with both sides starting to feel aggrieved.
Shea made a fine save to keep out Peter Murphy’s low piledriver from 25 yards before Sam Wood’s goalbound header was well blocked by Adam Barrett in the last real action of the half.
With all the pre-match hype surrounding prolific scorers Paul Hayes, Bayo Akinfenwa and Matt Tubbs, it was one of the unlikeliest of scorers who broke the deadlock six minutes into the second half.
Steven Craig beat Adam Barrett in the air and Josh Scowen saw the ball land at his feet before tucking it smartly past the keeper.
Peter Murphy went close twice from outside the area as the Blues looked capitalise on the momentum that Scowen’s goal had given them, and he clearly had a taste for goal as he embarked on a stunning run past three defenders before being denied by Shea inside the area.
A second goal seemed inevitable as Wanderers grew in confidence and it came courtesy of Sam Wood, who notched for the second game running with an instinctive close-range finish. Paul Hayes laid off a cross for Steven Craig and although the striker’s shot was heading wide, Wood was in the right place to double the lead.
The left midfielder could have had a second when he volleyed over from the penalty spot, but he needn't have worried as the Blues saw the game out to extend their unbeaten run to 10 games in Sky Bet League 2.
Wycombe: Ingram, Jombati, Jacobson, Mawson, Pierre, Cowan-Hall (Kretzschmar 85), Murphy, Scowen, Wood, Hayes (Bloomfield 90), Craig (McClure 81).
Unused subs: Richardson, Rowe, Lewis, Walker.
Wimbledon: Shea, Fuller, Smith, Bennett, Barrett, Francomb (Azeez 89), Nicholson (Pell 73), Moore, Rigg (Sainte-Luce 64), Akinfenwa, Tubbs.
Unused subs: McDonnell, Kennedy, Frampton, Fitzpatrick.
MOTM: Josh Scowen
Attendance: 4,329 (896 from AFC Wimbledon)
Winning 50/50 Draw Number: 118587
Prize Money: £691.50