Dean Morgan will be assessed after a reoccurrence of his hamstring problem.
The striker was forced off before the break in the 1-1 draw with Fleetwood Town, only his second game back since returning from injury.
Gareth Ainsworth said: "His hamstring's tweaked again, which isn't great. He's done all his rehab, he's done everything he could but unfortunately his hamstring seems to have cramped up again, or tweaked.
"We hope it's just a fascial tear and not the muscle itself."
Meanwhile, Jon-Paul Pittman could be involved in Saturday’s clash at Cheltenham Town after resuming full training over a week ago.
He said: "JP will definitely be in my thoughts for the weekend."