A second-half brace from Jacques Maghoma saw the Wanderers lose 2-0 at promotion-chasing Burton Albion.
The winger opened his account four minutes after the interval firing across Matt Ingram, before wrapping up the points in the 68th minute.
Gareth Ainsworth made one change to the side that won 1-0 at Morecambe on Saturday, recalling himself to the starting line-up at the expense of the suspended Stuart Lewis.
Dennis Oli, Bruno Andrade and Kortney Hause all missed out through illness with Matt McClure and Dean Morgan still sidelined by hamstring complaints.
Chairboys settled well but it was the hosts who enjoyed the early possession and top scorer Jacques Maghoma had the first shot of the game, but his eighth-minute strike from Alex MacDonald’s corner flew well wide.
Skipper Dave Winfield dived to bravely block Robbie Weir’s powerful strike in the 16th minute after good work from Maghoma.
However, the best chance of the opening stages came in the 20th minute when MacDonald found space on the right and cut back for Michael Symes just inside the Wycombe area, but the striker’s curling effort cleared the crossbar.
Ingram was called into action for the first time in the 26th minute and the 19-year-old did well to get his body behind Maghoma’s powerful effort after the midfielder’s initial free-kick had been blocked by the Wanderers wall.
A brief spell of Chairboys pressure forced a couple of corners and from one of these Ainsworth looped a header over the bar after Wood’s intended shot flew across goal.
Burton responded and Maghoma’s dangerous low cross evaded everyone, before Michael Symes’ far-post header from Anthony O’Connor’s centre drifted narrowly wide of strike partner Billy Kee, who would have had a tap-in.
Ainsworth forced Lyness into a save in the 38th minute when he volleyed Charles Dunne’s knock-down goalwards from 25 yards, but it was straight at the keeper.
Wanderers became more of an attacking threat as the half progressed and Grant linked up well with Kuffour before crossing from the right, but the advancing Josh Scowen was just too far away to convert.
The hosts took the lead four minutes after the restart through danger-man Maghoma. Harriman was unable to clear Lyness’ long clearance and the ball fell to Maghoma who fired across Ingram and into the far corner.
It would have been 2-0 three minutes later if not for Ingram. The keeper produced a fine finger-tip save high to his left to divert Kee’s curling effort away for a corner after the striker had turned Winfield.
Ingram then produced another superb stop in the 55th minute when he clawed away Lee Bell’s lob, which was destined for the top corner, before Symes shot wide from the edge of the area when well placed.
Maghoma added his and Burton’s second in the 68th minute with another clinical finish after breaking through the Blues defence and slotting past Ingram.
Symes came close to a third in the 73rd minute, but his curling effort from just inside the area drifted wide of the post.
Dunne’s looping header from Grant’s cross landed on the roof of the net seven minutes from time and Sharps clearance then crashed back off a team-mate before floating just wide.
Ainsworth made all three subs in the second half and the Chairboys finished the game with six youth team graduates after the introductions of Junior Morias, Jesse Kewley-Graham and Olly Taylor.
Wanderers: Ingram, Harriman, Dunne, Winfield (c), Doherty, Ainsworth (Morias 55), Scowen, Spring, Wood (Kewley-Graham 70), Grant, Kuffour (Taylor 79).
Subs: Harrison, McCoy, Johnson, Kretzschmar.
Burton: Lyness, O’Connor, McCrory, Holness, Sharps, MacDonald, Weir, Bell (c), Maghoma (Phillips 80), Kee, Symes (Paterson 85).
Subs: Tomlinson, Webster, Diamond, Dyer, Drury.