Wanderers have been drawn away to League 1 side Crewe Alexandra in the FA Cup first round.
The two teams last met in April 2011 when a brace from Scott Rendell earned the Chairboys a 2-0 victory at Adams Park.
Wycombe winger Joel Grant will be familiar face to Crewe fans as he enjoyed a three-year spell with the club before moving to Buckinghamshire in 2011.
The tie will be played on the weekend of 3rd/4th November. Ticket details and an exact date will be confirmed in due course.