Wanderers will be looking to build on their 1-1 draw with rivals Colchester United on Saturday when they travel to 20th placed Exeter.
The clash at St James' Park will see two of last season's League Two promoted sides go head-to-head in a battle that neither team can afford to lose.
Wycombe are still without a win on their travels this season and sit bottom of League One, but there is renewed hope around Adams Park following the Chairboys' impressive performance in Gary Waddock's opening game in charge against Col U last time out.
As for the Grecians, an inconsistent start to the campaign has left Paul Tisdale's side hovering just above the drop zone on 13 points and in need of a victory after heavy defeats to Huddersfield and Walsall respectively.
Only four positions and six points separate the two sides going into the clash in Devon and Blues defender Leon Johnson is confident the Wanderers can claim their first away victory of the season and close the gap on their weekend opponents.
He told Chairboys Player: "We can take a lot of heart from our performance against Colchester and hopefully we can take that into the game at Exeter and come away with the victory.
"We need to start picking up points and move away from the position we currently find ourselves in."
Build-up:
Waddock pre-Exeter
Johnson pre-Exeter
Extended Col U action
Waddock on Exeter test
Blues 5/2 to beat Grecians
Free Exeter commentary
Buy on gate for Exeter
Away guide: St James' Park
Opposition view: "I think we approach every home game hoping that we're the favourites, regardless of who the opponents are because that's the correct way to apply ourselves.
"We're just glad we're back at the Park (St James') with a home game after two fruitless long trips away from home
"Our priority is to make sure that our performance remains high and with that you hope that results come."
Exeter boss Paul Tisdale, speaking to BBC Radio Devon.
Team News:
Exeter: Paul Tisdale will be without suspended right back Richard Duffy for the clash in Devon. With regular keeper Paul Jones (knee) sidelined, experienced keeper Andy Marriott and on loan Tottenham youngster Oscar Jannson will battle it out for the number one spot.
Wycombe: Midfielder John Mousinho is back in contention after missing two games with a dead leg, while Marlon Pack has been passed fit after coming off in the draw with Colchester with a shin injury. Tommy Doherty is closing on a first team return but Gary Waddock won't rush him back into action.
Officials:
Referee: Mr S J Rushton
Assistants: Mr A A Laver and Mr M Pottage
Fourth Official: Mr M Philpott
Ticket News:
Tickets for the game can now only be purchased on arrival at St James' Park.
Prices:
Standing:
Adults: £15
Concessions(Over 60s/Students): £10
U18s: £5
Seating:
Adults: £17
Disabled: £15
Concessions: £12
U18s: £6
Live Commentary:
Chairboys Player will, as always, be providing live commentary from the League One clash with Ben Campbell reporting from St James' Park throughout the game. To sign up to your 14 day FREE trial, click here.
You can also receive text updates straight to your mobile phone by sending CLUB WYCW GOLD to 88442 and you'll receive team news, goal updates and scores around the division at a cost of 25p per message. To cancel the service at any time, just send STOP to the same number.
BBC Three Counties Radio (98FM) will be providing pre-match, half-time and full-time reports from the game and finally, don't forget to check wwfc.com after the game for a full report and reaction from the Wycombe camp.
