The Hornets, who finished 11th in the Championship last year, have seen major changes in the close season with Gianfranco Zola replacing Sean Dyche in the hot seat and a number of new players making the move to Vicarage Road.
Wycombe have a few links to Watford as both Joel Grant and Marvin McCoy started out at the Hertfordshire side and midfielder Matt Spring spent 18 months at the club, during which time they won promotion to the Premier League.
“It’s the first game I’ve been back for since I left and it was the best time of my football career when I was there,” Spring told Chairboys Player.
“I was only there one season and getting promoted to the Premier League is everyone’s dream really. My only regret is that I didn’t get the opportunity to play a bit more and I should never really have left.
“Once you get told you’re not really wanted it’s hard to stick around. Looking back I should have tried to see where it would have gone, but that’s gone now and I’ve moved on.
“Nearly everyone has gone since I was there, only Lloyd (Doyley) is still there out of the players that I played with. There have been big changes and I think it will be a different Watford this year than we have known from previous years.”
Boss Gary Waddock is expecting a tough test for his side against a team two divisions above, but says it is a match that the whole squad is excited for.
“With a new manager and the new group of players that he is assembling there, it is a very good game for us,” Waddock told Chairboys Player.
“It will be a big test. They are a Championship club and the manager is experienced and has worked at the top level.
“The players that he has been able to bring into the club have a lot of experience and have played at the top level so it will be a tough, tough game for us, but it's one that we are looking forward to.
“We have everything to gain and nothing to lose, but we want to go there and see if we can get into the next round.
“When you break it all down they are a Championship club and we are in League 2. People will look at the game and expect one result, but we are going into it in a positive frame of mind.”
Tickets for the game are available on the day at Vicarage Road and are priced at£10 for adults, £5 for concessions and just £1 for juniors.
Don't worry if you can’t make it to the game as Ben Campbell and Matt Sadler will be providing live and exclusive commentary on Chairboys Player from 2.55pm - click here to sign up.