Two first-half penalties saw Wycombe and Yeovil share the points at Adams Park with Joe Jacobson cancelling out Kevin Dawson's earlier spot-kick.
Sido Jombati fouled Francois Zoko to give the Glovers the opportunity to take the lead, which they held for little more than four minutes when Jacobson converted the penalty awarded when Alex Lacey tripped Paris Cowan-Hall.
Blues pushed for a winner in the second period but the visitors held firm to continue their unbeaten record in all league games at Adams Park.
Gareth Ainsworth handed a start to Myles Weston in attack in place of Scott Kashket, who is yet to recover from a knock sustained in the FA Cup win against Stourbridge, while Sam Wood lined up in midfield with Matt Bloomfield out injured.
Francois Zoko would prove to be a handful for the home defence and proved his threat inside 30 seconds, skipping away down the left and delivering a dangerous cross which was diverted goalwards by Ben Whitfield, requiring Aaron Pierre to make a vital clearance.
Luke O’Nien headed an inviting cross from Myles Weston just wide of the post before Dominic Gape struck the woodwork with a superb drive from 30 yards, leaving the keeper flat-footed as he watched it fly towards the top corner.
Wycombe were just beginning to exert their dominance when Yeovil were awarded following a foul by Sido Jombati on Zoko inside the area, and Kevin Dawson made no mistake from the spot, sending Jamal Blackman the wrong way.
But within four minutes, the scores were level and the goal came from another penalty, this time at the other end when Paris Cowan-Hall was tripped by Alex Lacey and Joe Jacobson kept his cool – despite a delay for treatment to Dawson – by stroking the ball into the corner.
Wanderers then came close to taking the lead when Cowan-Hall fed O’Nien who stung the palms of Yeovil keeper Artur Krysiak with a powerful effort, and then Omar Sowunmi glanced a header wide for the Glovers from a cross from the right.
O’Nien was involved in plenty of Wycombe attacks, and hit the target with a well-taken volley on 38 minutes, and they finished the half on top without further testing Krysiak.
With no changes at the interval, both sides looked to take the lead early in the second period with O’Nien’s looping header being well cleared before the Glovers broke and Ben Whitfield tested the handling of Jamal Blackman at the other end.
Anthony Stewart returned to the field after landing awkwardly on his header before Omar Sowunmi broke into the box to tee up Whitfield, who fired over the bar under pressure from Joe Jacobson.
However, Stewart soon judged himself to be unable to continue so Will De Havilland took his place in defence, shortly after Jamal Blackman and Nathan Smith were both booked for their part in a coming-together inside the Wycombe box.
Paul Hayes came off the bench on 74 minutes, taking the place of Myles Weston, but other than a comfortable save from Akinfenwa’s flicked header, there was little goalmouth action to speak of.
Garry Thompson stepped onto the pitch as the Chairboys’ final substitution, replacing Sam Wood, before Dominic Gape threaded a great ball through for Cowan-Hall, only for the winger to miscue his shot at the vital moment.
The same combination paired up for a similar opportunity as the clock ticked towards 90, but this time Cowan-Hall was forced wide and his cross-shot was held by Krysiak.
Eight minutes of stoppage time presented the opportunity for both sides to find a late winner, although Yeovil boss Darren Way opted to bring on a defender for a striker to seemingly settle for a point.
And he’ll have been the happier of the two managers as his side left Adams Park with a point – the first draw on this ground since August.