Lee Molyneux fired home an injury-time winner as the Blues were beaten 1-0 by Accrington Stanley.
Wanderers created more openings than their opponents and enjoyed more possession, but they failed to test Paul Rachubka enough and Molyneux’s late show secured the points.
However, the midfielder might count himself lucky to still be on the pitch after appearing to kick out at Matt Ingram in the first half.
Ingram was in for his professional debut in place of Jordan Archer who was recalled by Tottenham Hotspur and boss Gareth Ainsworth made a further three changes with Marvin McCoy, Leon Johnson and Jo Kuffour in the side.
Dave Winfield, who had been struggling with illness throughout the week, was on the bench, as was Charles Dunne, while Dean Morgan missed out with a hamstring injury.
Stuart Lewis came close to lobbing home the opener in the eighth minute when Paul Rachubka’s punch fell for the midfielder 20 yards out, but his chipped effort was palmed away for a corner.
Kuffour then flashed a strike over the bar from outside the area as the Blues started the better of the sides.
Scowen had an effort bravely blocked by an Accrington defender after Rachubka flapped at a Wood corner and in the same goalmouth scramble Doherty headed Wood’s cross wide.
Lee Molyneux appeared to kick out at Ingram after the keeper collected a cross in the 20th minute, but the referee only gave the Stanley player a yellow card much to the disgust of the terrace.
Molyneux almost made full use of his reprieve minutes later, but his left-footed long-ranger curled wide of the post.
Sam Wood’s 25-yard free-kick was comfortable for Rachubka 10 minutes before the break and then Kuffour was released by Lewis’ flick, but the striker was unable to pick anyone out in the middle.
The returning Johnson should have made it 1-0 with eight minutes of the first half remaining, but he got his angles wrong and headed Joel grant’s inviting cross well wide from six yards.
Lewis was denied by the post two minutes after the break after breaking forward from midfield and being found by McClure, before Grant’s spectacular overhead kick drifted wide.
Rommy Boco curled wide harmlessly wide for the visitors, but it was Ainsworth’s men who were the next to come close when Scowen curled a 58th-minute free-kick over the wall, only for Rachubka to parry away.
Kuffour threatened to break clear from Lewis’ flick in the 66th minute, but he took the ball out too wide and the chance had gone.
Junior Morias was introduced in the 69th minute as Ainsworth utilised his attacking options from the bench, however, it was Stanley’s Amine Linganzi who came close when he half-volleyed narrowly wide following Will Hatfield’s deflected cross.
Morias thought he had played McClure in on goal with eight minutes remaining, but the striker ran just too early and was narrowly offside.
Wood came closest of anyone to securing a winner for the Blues when McClure flicked on to Lewis and the ball broke to the winger on the edge of the area, but his drilled left-footed effort went wide of the far post.
However, the visitors had the final say in injury-time when Molyneux smashed home from just inside the area after the Wanderers has failed to clear a corner.
Wycombe: Ingram, McCoy, Harriman, Doherty (c), Johnson, Grant (Ainsworth 77), Scowen, Lewis, Wood, Kuffour (Morias 69), McClure.
Subs: Harrison, Dunne, Winfield, Spring, Ainsworth, Andrade.
Accrington: Rachubka, Wilson, Aldred, Winnard, Murphy, Linganzi, Joyce (c), Hatfield (Gray 88), Molyneux, Boco (Lindfield 75), Beattie (Amond 85).
Subs: Dunbavin, Liddle, Miller, Clark.
Attendance: 4,577 (112 Accrington)