Goals from Matt Bloomfield, Grant Basey (pen) and top scorer Stuart Beavon proved in vain as Alan Judge's injury-time effort condemned the Blues to a 4-3 defeat and relegation.
Wanderers led three times during the game and played some great football at times, but were pegged back by Daniel Bogdanovic, Judge and Dele Adebola, before Judge struck again to settle the contest.
Wycombe made the perfect start and took the lead with only 37 seconds on the clock. Stuart Lewis found Matt Bloomfield on the right and the midfielder cut in before firing left-footed past Stuart Nelson, who probably should have done better.
However, that lead lasted only two-and-a-half minutes as Wanderers failed to deal with a break down the left and a low cross eventually found Daniel Bogdanovic who placed his shot into the corner of Nikki Bull's goal from eight yards
Bloomfield tried his luck from distance again in the 11th minute and Nelson could only parry the ball straight to Ben Strevens, but a combination of the keeper and centre-back Damion Stewart rescued County.
Blues kept pushing forward and deservedly retook the lead five minutes later. Strevens did brilliantly on the left to dispossess a County defender and the ball fell to Stuart Beavon, who broke into the area before being upended by a clumsy challenge from Stewart.
Grant Basey, who missed a late spot-kick against Oldham in the last match at Adams Park, stepped forward and confidently fired the ball to Nelson's left.
Veteran striker Dele Adebola came close to levelling just past the half-hour mark, but he was just unable to reach Kieron Freeman's dangerous low cross.
Beavon broke clear in the area and his angled drive was well saved by Nelson, but it was County who struck five minutes before the break.
A quick free-kick found Alan Judge on the left and he cut inside Gareth Ainsworth before rifling an effort inside Bull's near post from the edge of the area.
The visitors almost took the lead in first-half injury-time when Stewart hooked Judge's corner goalwards, but Marvin McCoy was perfectly placed to head over the bar.
Adebola should have given County the lead two minutes after the break, but his header from point-blank range was straight at Bull, who did well to react in time.
McCoy had Wycombe's first effort of the half when he fired over from 25 yards before Ainsworth's effort was comfortably gathered by Nelson.
Bull came to the Blues' rescue in the 57th minute when he kept out Judge's stinging effort after the midfielder had linked up neatly with Lloyd Sam.
Wanderers took the lead for a third time in the 67th minute. Joel Grant found Bloomfield in the area and he cleverly flicked the ball into Beavon's path and Wycombe's top scorer made no mistake, curling past Nelson and into the bottom right corner.
Substitute Lee Hughes had a header ruled out for offside and Jeff Hughes was then denied by Bull as County went in search of another equaliser.
That equaliser came two minutes from time when Adebola was given too much space and he headed in Jeff Hughes' cross from close-range.
Both sides piled forward in search of a winner and it was County that grabbed a fourth in injury-time. Leon Johnson failed to clear his lines on the edge of the area and Judge crashed home his second stunning effort of the game.
Wanderers: Bull (c), McCoy, Basey, Doherty, Johnson, Bloomfield, Eastmond, Lewis, Strevens (Ainsworth 26), Grant (Dunne 83), Beavon.
Subs not used: Foster, McNamee, McClure.
Notts County: Nelson, Freeman (Demontagnac 82), Sheehan, Edwards, Stewart, J Hughes, Bishop (c) (Mahon 62), Judge, Sam, Bogdanovic (L Hughes 62), Adebola.
Subs not used: Spiess, Bencherif.