Two fine goals from Stuart Beavon and a rare strike from Dave Winfield handed the Blues an important victory over fellow strugglers Rochdale at Adams Park.
The striker lifted the ball past Peter Kurucz to settle a tame first half and doubled the lead on 73 minutes with a stunning piece of skill and sublime finish into the corner.
Winfield then extended the Blues' advantage with a close-range finish from a corner, meaning a first victory of 2012 was never in doubt.
The hosts were also able to enjoy a first clean sheet since September, with teenage Louis Laing impressing at the back on his maiden Wycombe appearance.
The Blues settled the better of the two sides and won a succession of corners in the first 10 minutes, with Dave Winfield's miscued volley the closest they came to registering a shot on target.
Dale's first effort came from Jason Kennedy on 15 minutes but his left-footed strike from 20 yards trickled past Nikki Bull's post as the game became more even with neither side dominating.
But just as the game was looking bereft of any spark, Stuart Beavon lit up Adams Park with some superb attacking play, outmuscling Kevin Amankwaah from Ben Strevens' flick-on before lifting the ball past the keeper to open the scoring.
Beavon then dragged an effort wide from a tight angle as the Blues pressed for a second, while Gary Jones sliced his volley from 20 yards at the other end with neither keeper being forced into any meaningful saves before the break.
Shots on target were again in short supply at the beginning of the second period but Dale improved going forward and began to stretch the Wanderers defence, although the impressive pairing of Laing and Dave Winfield repelled everything that came their way.
Meanwhile, the Wanderers were looking strong on the break, with Beavon, Joel Grant and Kadeem Harris linking up well, and Matt Bloomfield and Stuart Lewis saw shots blocked as they looked to put the game beyond reach.
It took a fine sliding challenge from Grant Basey to prevent substitute Ashley Grimes from pulling the trigger as he raced through on goal, before Beavon's second of the game calmed any nerves around the stadium.
With the confidence and skill of a top-flight striker, Beavon took down a cross on his thigh and shot on the turn, finding the top corner in impeccable fashion to notch up his 13th goal of the season in all competitions.
The celebrations had barely died down by the time Dave Winfield netted his first of the campaign, flicking home with the side of his foot after failing to make a proper connection with a corner from the right in the first instance.
Wanderers could sniff only their second clean sheet of the season but it needed a fine save from Nikki Bull to turn behind a deflected effort on 80 minutes.
There was the chance for Gary Waddock to hand a debut to young midfielder Jesse Kewley-Graham in stoppage time and the referee's whistle sounded with no further incident, confirming a valuable three points for the Blues.