A late header from second-half substitute Francois Zoko denied the Blues all three points from an entertaining encounter at Brunton Park.
Rory Loy gave Carlisle the lead with fewer than two minutes on the clock, poking the ball past Nikki Bull&nbsp;from close range..
Anthony McNamee levelled with an unstoppable 25-yard curling effort before Marcello Trotta gave Wycombe the lead courtesy of a fine low drive.
But Zoko popped up four minutes from time to earn a share of the spoils for the seventh-placed side.
Gary Waddock kept faith with the side that finished the 3-2 win over Chesterfield for the clash in Cumbria.
Matt Bloomfield started in midfield in place of the injured Scott Donnelly after impressing as a substitute against the Spireites, while loanees Trotta and McNamee were again included in the starting XI.
Wanderers made the worst possible start to the game, going behind inside the first 90 seconds courtesy of Rory Loy's close-range finish.
A moment of magic from Joel Grant almost brought about a quick response but, after tricking his way past Lubomir Michalik, he couldn't beat Adam Collin from 15 yards.
Collin was again called into action shortly afterwards, this time pulling off a stunning fingertip save from Trotta's curling effort.
Despite being on the backfoot since Loy's early strike, Greg Abbott's men almost extended their midway through the half but Bull got down quickly to deny Liam Noble from eight yards. .
At the other end, Trotta hit the post with a poked effort from a tight angle as Carlisle's goal continued to live a charmed life.
Wycombe's pressure finally told on 28 minutes when McNamee curled home an unstoppable 25-yard effort to add to his volley in last week's win at Adams Park.
Eight minutes later and the Blues were in front thanks to Trotta, the man of the half. The Fulham loanee latched on to Stuart Beavon's inch-perfect pass inside the box before drilling home his third goal in three games to send a Santa-infiltrated away following into raptures.
Loy was the first to threaten after a fairly even opening 10 minutes of the second half, drawing a fine stop from Bull diving away to his left.
Some unsavoury scenes followed, but none of the officials saw what looked like a deliberate stamp by Lee Miller on Trotta after the Italian striker had got the better of the Cumbrians frontman.
Abbott introduced Tom Taiwo, Francois Zoko and Paddy Madden in a bid to try and turn the game in the hosts' favour but the Blues backline continued to held firm.
Beavon drew a good save from Collin as Waddock's men looked to wrap up victory on the counter-attack, but instead they found themselves being pegged back not longer after when substitute Zoko headed Jon-Paul McGovern's cross past Bull.
There was still time for a McNamee cross to whistle just past Carlisle's left-hand post and a&nbsp;Michalik free-kick to be well parried by Bull, but both sides had to settle for a point in an entertaining encounter.
Wanderers: Bull, McCoy, Basey, Winfield, Johnson, Grant, Lewis, Bloomfield, McNamee, Trotta, Beavon.
Subs: Foster, Rowlands, Ainsworth, Harris, Strevens.
Goal: McNamee (28), Trotta (36).
Cautions: Johnson, Lewis.
Carlisle: Collin, Simek, Robson, Michalik, Murphy, Thirlwell (Taiwo 55), Berrett,&nbsp;Noble (Zoko 65), McGovern, Loy (Madden), Miller.
Unused subs: Gillespie, Livesey,
Goal: Loy (2), Zoko (86).
Cautions: Berrett, Zoko.