Wanderers gave MK Dons an almighty second-half scare but ultimately succumbed to a 4-3 victory in a thrilling Bucks derby at stadiummk.
Dean Bowditch swept home the opener for the hosts and they could have been out of sight by the break, missing a number of chances although Wycombe felt aggrieved not to have been awarded a penalty for a clear foul on Joel Grant.
However, the Blues turned the game on its head after the break thanks to a superb drive from Stuart Beavon and a cool finish from debutant Marcello Trotta after a defensive mistake.
But Bowditch levelled the scores soon after and further goals from Jabo Ibehre and Mathias Doumbe ensured the points would remain in the north of the county, although an incredible 90th minute blast from Beavon set up a nailbiting finale.
Wanderers survived an early scare when Nikki Bull had to tip Grant Basey's inadvertent clearance over the bar under pressure from Charlie MacDonald.
Gary Waddock's men threatened twice in quick succession shortly afterwards - firstly Joel Grant firing over the top from 25 yards before Stuart Lewis dragged an effort wide after smart build-up play by Kadeem Harris and Trotta, who both looked impressive early on.
But it was the hosts who took the lead on 14 minutes when Stephen Gleeson cut inside Basey and arrowed a strike past Bull from 15 yards.
Dons should have extended their advantage not long after, but an unmarked Jabo Ibehre was denied by a superb stop by Bull after a smart counter attack. Ibehre was again involved a minute later, this time turning provider for Luke Chadwick who curled over an unguarded goal after Bull had tried to deny Ibehre.
Dons continued to dominate proceedings, but they should have been down to 10 men and conceded a penalty just after the half hour mark when Grant was hauled down by Mathias Doumbe in front of goal. Inexplicably, nothing was given.
Joel Grant should have been awarded a penalty for this foul
Grant then missed Wycombe's best opportunity of the half, curling an effort into the arms of Martin after being picked out by Trotta, while, at the other end, Bull had to alert to thwart the lively Ibehre following another swift Dons counter-attack.
Harris saw a fine 25-yard effort saved before ex-Dons loanee James Tunnicliffe scooped a close-range effort over the bar from Grant Basey's resulting corner as a hugely-entertaining first half came to a close.
However, nobody could have imagined what was to come in the first 10 minutes of the second period, with three goals lighting up North Bucks.
Firstly Stuart Beavon drilled a stunning strike into the top corner after excellent work from Scott Donnelly down the left, making it 1-1 and giving the visitors an extra spring in their step.
And the excellent away support were on their feet once again within two minutes as Marcello Trotta seized upon a loose pass to Dean Lewington to stroll into the area and clip home to mark his debut with a classy finish to put Wycombe ahead.
But MK Dons' attacking quality brought them level on 55 minutes when Luke Chadwick escaped down the right and James Tunnicliffe could only deflect the ball into the path of Dean Bowditch, who made no mistake from 12 yards.
Joel Grant spurned another great opportunity just past the hour-mark when he received a lay-off from Trotta and fired too close to David Martin, and the Blues were left to rue that miss when Jabo Ibehre swung the game back in the Dons' favour.
Charlie MacDonald collected the ball on the right side of the box and delivered a low ball towards the penalty spot, where Ibehre controlled it neatly and fired home on the turn.
The lead was doubled on 70 minutes when Mathias Doumbe rose highest to head home Stephen Gleeson's corner from the left and finally the frantic nature of the game began to die down as Dons knew their points were safe.
The hosts enjoyed all of the attacking pressure as the clock ticked towards 90 but there was hope when Beavon smashed home his 10th
of the season with a phenomenal strike from 25 yards.