Gary Waddock celebrated his 100th game in charge of the club with possibly the best result during his Wycombe career, defeating Sheffield United at Adams Park and ending their five-game winless and goalless run at the same time.
Stuart Beavon was the hero, capping a man-of-the-match display with the only goal in the first half, carrying the ball into the area and finding the top corner in style.
It was a bright and refreshing performance all round from the hosts, who created a number of chances to extend the lead and held firm at the other end when required.
The result also marks Wycombe's first clean sheet of the season ahead of the visit of Preston North End on Tuesday evening.
There were three changes to the side with Stuart Beavon returning up front, while Kadeem Harris was handed a first ever Football League start, joining the returning Ben Harding in midfield.
Beavon was amongst the action in the first three minutes when his snapshot towards the near post was saved by Steve Simonsen, before the hosts showed their attacking intent by leaving three players forward for a United corner.
However, they were forced to endure long spells without possession as the visitors showed their class with a range of passing, although their only sight of goal past a stubborn Wycombe defence was a wayward 20-yard shot from Michael Doyle on 16 minutes.
At the other end, an opportunistic drive from 35 yards from Scott Donnelly almost caught at Simonsen, while Lee Williamson headed over the bar for United after great work from Chris Porter down the right.
Wycombe's resilience was impressive, and it was the same never-say-die attitude that brought about their first league goal since 16th August on 31 minutes. Stuart Lewis' pass forward fell kindly for Stuart Beavon but there was still work to do as he took the ball on and fired superbly into the top corner.
The strike brought Adams Park to its feet, with that long wait to break the duck finally over, and all of a sudden a new-found confidence oozed through the side, with Beavon and Lewis shooting wide from decent opportunities.
Williamson came close for Danny Wilson's men with a left-footed daisy-cutter which fizzed just past Nikki Bull's post before the half came to a close, with Wycombe's fans delighted with what they'd seen.
A lightning-quick break from Kadeem Harris just after the interval resulted in his shot being palmed around the post for a corner, before Ched Evans rattled the crossbar with a sensational volley from 25 yards which might have just brushed the fingertips of Nikki Bull.
Joel Grant had a great chance to double the lead on the hour-mark when Beavon's pass to Ben Harding inside the area was knocked on to him at the back post, but the winger shinned his effort past the post with Simonsen struggling to clamber across.
Grant then stung the palms of the keeper with a powerful strike after tricky footwork from Scott Donnelly, before Simonsen was again called upon to hold on to Kadeem Harris' low cross as the home fans cranked up the volume, buoyed by the positive display from their side.
However, United were second in the league for a reason, and they responded excellently, first seeing Nikki Bull dart off his line to block Ched Evans' shot before tipping the follow-up superbly over the bar.
Looking to capitalise on the shift in momentum, Danny Wilson made two changes in quick succession, bringing on Lecsinel Jean-Francois and the experienced Richard Cresswell, but it was Wycombe who had the next chance, seeing Andy Sandell's teasing free-kick glanced on by Leon Johnson but just lacking the conviction to beat Simonsen.
Ched Evans missed a glorious chance when given space inside the area on 80 minutes but it was a rare lapse from the home defence, who continued to throw their bodies on the line to thwart the Blades, and when they were beaten, Nikki Bull was equal to everything that came his way.
The result was celebrated with a huddle on the pitch by all Wanderers players, displaying publicly what it meant to everyone involved.