Poor defending from set pieces was Wycombe's undoing at Prenton Park as they succumbed to a 2-0 defeat to Tranmere Rovers.
The hosts were in front inside the first nine minutes when Enoch Showunmi tapped home after Lucas Akins returned Ian Goodison's header into the six-yard box following a free-kick from deep.
After a disappointing first-half showing from both sides, Wanderers looked more enterprising in the second period but shot themselves in the foot when Ash Taylor lost his marker to find the net from a corner just after the hour-mark.
A new-look attack spearheaded by Gareth Ainsworth couldn't turn the tide and the Blues were left to reflect on a fifth straight loss without scoring.
Ainsworth returned to the side after recovering from a back complaint, but Stuart Beavon missed the trip to Birkenhead following a setback in training on Friday.
Tranmere capitalised on a strong start by taking the lead in the ninth minute, Showunmi firing home from close range after Akins returned Goodison's header into the six-yard box following John Welsh's free-kick from deep.
The impressive Akins then drove an effort wide after being picked out at the backpost by Robbie Weir, while, at the other end, Elliot Benyon poked Ben Strevens' clever cross just past the post as the Blues looked for a quick response. However, that proved to be the only real foray forward for the Wanderers in an opening 30 minutes that the hosts dominated.
Les Parry's men had two further chances to enhance their lead before the break, but Adam McGurk dragged his effort wide of the left-hand post before Showunmi headed in the arms of Nikki Bull from six yards.
Wanderers showed signs of improvement after the interval, keeping the ball better in advanced areas, but that hard work came undone just after the hour-mark when Ash Taylor was gifted a free header to double the lead from a drilled corner towards the near-post. The defending left a lot to be desired and Wycombe were left facing a huge uphill battle, bringing on Matt Bloomfield and Ben Harding in a bid to turn the game.
A half-chance was presented to Stuart Lewis when the ball bounced up to him and his header looped over the crossbar, before Scott Rendell came off the bench to partner Gareth Ainsworth in attack.
But aside from Ainsworth's dragged effort from 20 yards which trickled wide of the far post and a volley from Lewis which cleared the bar, the visitors still struggled to create chances to earn a route back from their impending defeat.