Wycombe somehow suffered a 1-0 home defeat to local neighbours Brentford as a controversial penalty stole the points for the visitors.
Clayton Donaldson took a tumble after the softest of touches from James Tunnicliffe but saw his side awarded a spot-kick - much to the astonishment of Wanderers players and fans alike - and Kevin O'Connor slotted home.
The hosts threw everything at the Bees after the interval but found keeper Richard Lee in inspired form, keeping out efforts from Scott Donnelly, Ben Harding and Andy Sandell.
Brentford clung on to an undeserved three points and the Blues will look to return to winning ways when they travel to Yeovil Town on Tuesday night.
It was no surprise to see Stuart Beavon handed a starting berth following his midweek hat-trick against Bristol Rovers in the Johnstone's Paint Trophy, although there may have been a few raised eyebrows at the absence of captain Gareth Ainsworth, who had to settle for a place on the bench with Ben Harding coming into the side.
There was a scare inside 30 seconds when Clayton Donaldson found space inside the area and fired towards Nikki Bull's near post, but the ex-Brentford keeper was equal to it and parried it away to safety with two strong palms.
Donaldson then fired over from 20 yards when the ball cannoned into his path after Leon Johnson blocked Kevin O'Connor's effort, with the visitors looking to continue their run of form which had seen them win four of their opening six games in npower League 1.
Jonathan Douglas then jinked into the box and fired another goalbound drive which was kept out by Marvin McCoy's diving challenge, but the Blues were struggling to retain possession on a greasy surface and continued to hand the initiative to the away side.
They were also the beneficiaries of a number of free-kicks and corners around the Wycombe penalty area which contributed further to the hosts being pressed onto the back foot. However, as the sun came out, it sparked new life into Gary Waddock's men and they began to look more inventive going forward, seemingly helped by the increased volume in the ground which had been sparked by a couple of feisty tackle on the pitch.
However, it was possibly the softest of the game which brought about Brentford's penalty on 35 minutes when Myles Weston tumbled to the floor under the slightest of touches from James Tunnicliffe, running away from the area. The referee - who had awarded Wycombe two spot-kicks in their last encounter at Adams Park - pointed to the spot and Kevin O'Connor found the net to open the scoring.
Aggrieved by the decision, Wycombe looked to fight back with a vengeance and twice went close, firstly seeing Beavon poke wide before Richard Lee kept out Ben Strevens' volley from close range.
The half-time whistle was met with boos - not at the Wanderers' players, who had done enough in the game to be level - but towards the referee, whose soft decision had given Brentford an unjust advantage.
However, the hosts came close to levelling soon after the interval when Scott Donnelly's free-kick needed fingertips from Richard Lee to divert it over the crossbar, before Ben Harding's fierce drive fizzed just inches over the top courtesy of a deflection.
Stuart Beavon then had the ball taken off the tip of his boot just as he was set to pull the trigger after some fine work latching on to a through-ball, with Wycombe in the ascendancy against a well-drilled but very ordinary Brentford side.
Ben Strevens then hit the woodwork with a flicked header once James Tunnicliffe had returned Scott Donnelly's deep free-kick into the six-yard box, before Donnelly's superbly hit effort from distance was acrobatically turned behind by Lee as the pressure intensified.
It was pure one-way traffic, with Marvin McCoy's left-footed shot swerving narrowly wide on 63 minutes, before a spate of substitutions temporarily took the sting out of the game.
Nevertheless, Wycombe huffed and puffed and kept searching for the equaliser, seeing another Donnelly effort parried away by Lee and Andy Sandell's curling free-kick tipped around the post.
While Brentford offered nothing in attack, they had somehow clung onto a lead they never deserved and they owed a lot to their keeper, Richard Lee, for a succession of fine stops. Another Donnelly piledriver flew over the top in the five minutes of stoppage time, but it wasn't Wycombe's day, and for the second home league game running, they were left reflecting on what might have been had the big decisions gone their way.
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