Wycombe's long unbeaten run finally came to an end at Adams Park as Bury claimed a 2-0 victory in controversial circumstances.
Mike Jones scored the only goal of an even second half, firing home after a smart lay-off from Ryan Lowe, before the drama kicked off after the break.
The hosts were denied a clear penalty when Joel Grant's shot hit a hand inside the area before Lowe doubled the visitors' lead with a toe-poke from 12 yards.
Bury's talisman should then have seen red for a nasty tackle on Joel Grant and shoving Andy Sandell with two hands, but despite failing to test Nikki Bull aside from their two goals, the Shakers held on for the win.
It was a bright start from the unchanged Blues and they looked lively in all areas of the attack, seeing Joel Grant flash a 20-yard strike wide and Scott Donnelly beat the offside trap before missing the target with a cross-shot with the outside of his foot.
There was a scare at the other end when David Worrall was picked out in space inside the area but bizarrely chose to pass, ending the move and keeping the game scoreless.
The opening goal came on 24 minutes and it was a smart move involving dangerman Ryan Lowe which did the damage. Lowe held the ball up on the edge of the box and Michael Jones ran from deep to collect the pass inside the area, firing a shot into the net via the inside of Nikki Bull's left-hand post.
Wycombe pressed for a response and created their best opening on 40 minutes when Danny Foster was released down the right wing, sending in a teasing cross which was headed into the arms of the keeper by a towering Ben Strevens.
An uneventful first 45 minutes ended with the visitors in front but it took a smart save from Cameron Belford to retain the lead, tipping Scott Donnelly's free-kick over the bar, before Andy Sandell's downward header was blocked en-route to goal from the resulting corner.
At the other end, an exquisite chip from Andy Bishop was inches away from doubling Bury's advantage, bouncing off the top of the crossbar, before Gary Waddock responded by bringing on Ben Harding for John Halls with 54 minutes on the clock.
Wycombe were denied a clear penalty when Joel Grant's shot hit a hand inside the area, prompting outrage from fans and players alike, before Elliot Benyon came off the bench for his home debut.
Dave Winfield rose highest to head into the keeper's arms from a Donnelly corner on the hour-mark as the pressure intensified, but the Shakers reacted well and scored their second on 65 minutes.
After Andy Bishop had headed wide from a good position, he supplied Ryan Lowe inside the area and the striker was given too much time and space to work an opening before poking past Nikki Bull into the far corner.
The striker should then have seen red for kicking Joel Grant before raising his hands to Andy Sandell in the ensuing confrontation, but the referee somehow deemed the incident to be worth no more than a yellow card.
Further chances were hard to come by as the Shakers produced a stubborn display - with a sideshow of time-wasting thrown in for good measure - although Elliot Benyon should have netted a consolation in stoppage-time when the ball fell to him eight yards out.
The Blues will now look to bounce back with a Carling Cup giant-killing when they take on Nottingham Forest on Tuesday night at Adams Park.
50/50 Draw | Prize Fund: £568.00 | Winning Number: 112589