Wycombe endured a disappointing 1-0 defeat to Stevenage at Adams Park as a long-range effort from ex-Wanderer John Mousinho grabbed the points for the visitors.
Boro created the better openings in a goalless first half but took the lead moments after the interval when Mousinho found space 25 yards out and rifled an effort past Nikki Bull.
The keeper needed to be at his best to deny Darius Charles and Chris Beardsley to maintain the one-goal deficit and not even a red card for Scott Laird could swing the game back in Wycombe's favour.
The best opportunity fell to Danny Foster on 88 minutes when he slid in at the near post but couldn't make contact with an excellent low cross from Marvin McCoy.
There was a scare 10 minutes in when the ball fell kindly for Byron Harrison in the box after a mini goalmouth scramble but a combination of McCoy and Bull resulted in the striker's effort spinning just wide.
But the hosts should have been in front five minutes later when a smart combination down the left between Kevin Betsy and Ben Strevens released Matt Bloomfield on the edge of the box, although after shifting the ball onto his left foot, the midfielder could only send his powerful shot over the bar.
Rob Sinclair fizzed a low free-kick wide at the other end as Boro began to stamp their authority on the game, with John Mousinho then sending a diving header wide of the near post.
However, Wycombe grew in stature and looked more threatening as the half wore on, while Mousinho went into the book for a late tackle on Stuart Lewis with the tempo rising.
Nikki Bull needed to produce a smart diving save to keep out Scott Laird's curling free-kick on the stroke of half-time and it proved to be the last real action of the opening 45 minutes, which had seen Stevenage probably edging it in terms of attacking threats.
A change at the break saw Lewis Montrose replace Stuart Lewis, whose injury from Mousinho's challenge was too severe for him to continue, and the Blues were dealt a further blow two minutes into the second half when Mousinho's long-range effort beat Nikki Bull and found the corner of the net.
The midfielder could have counted himself lucky to be on the pitch after his foul on Lewis and the sense of injustice only served to frustrate the home fans.
It was clear from Stevenage's physical approach that they were only content with settling for their one-goal lead and the match suffered as a spectacle, although the Wanderers were indebted to a fine save from Nikki Bull as he kept out Darius Charles with an instinctive hand to his right.
Wycombe were handed a lifeline when Scott Laird saw red for a second bookable offence on 67 minutes, and they responded by bringing on Jon-Paul Pittman for Gareth Ainsworth.
But despite the numerical advantage, the turnaround was nowhere near forthcoming and only another stunning save from Bull kept out Chris Beardsley's header on 76 minutes.
Pittman sent a bicycle kick wide after Boro failed to clear a corner and Danny Foster failed to make a proper connection on a superb low cross from Marvin McCoy with the goal at his mercy as Boro held on for the win.