Kevin Betsy's 82nd minute strike handed Wycombe all three points against Bradford City in a controversial encounter on Peter Taylor's return to Adams Park.
The first half produced some entertaining football from both sides, although neither team were able to produce enough goalscoring opportunities to break the deadlock.
But then the game sprang to life when former Wanderer Tommy Doherty was shown a straight red card for a two-handed shove on Gareth Ainsworth just past the hour-mark.
The winning goal itself was clouded in controversy as City appealed for a decision for the linesman but Wycombe played on and the ball broke to Betsy, who kept his cool to roll home and clinch the victory.
Tommy Doherty's red card was a major talking point
Gary Waddock restored his first-team regulars to the starting line-up following the midweek Johnstone's Paint Trophy defeat to Bristol Rovers, and the opening to the game matched Tuesday's clash for entertainment with both sides pushing for an early goal.
Omar Daley saw two efforts flash wide within the first eight minutes while at the other end, the ever-inventive Stuart Beavon was involved in a whole host of smart moves, creating chances for himself and Ben Strevens to test the keeper.
Wycombe were probably bossing the possession stakes but Bradford's counter-attacking game often looked threatening and only a superb challenge from Dave Winfield denied Omar Daley a clear shooting chance from six yards following good work from Jason Price.
At the other end, the deadlock was almost broken when Gareth Ainsworth's inch-perfect cross was glanced towards the corner by Stuart Beavon, but Lenny Pidgeley made a fine finger-tip save to turn it behind for a corner.
Goalscoring chances were probably even throughout the first half although City finished on top, forcing a number of corners, one of which resulted in Dave Winfield needing stitches after a nasty collision with Dave Syers.
With no changes at the break for either side, Wycombe looked more enterprising at the start of the second period and the careless handling of City keeper Lenny Pidgeley gave the Blues reason for optimism, resulting in several crosses being directed towards the visitors' area.
And the game burst into life just after the hour-mark when Tommy Doherty was shown a straight red card for shoving Gareth Ainsworth in the face following an innocuous looking challenge. The former cult hero of the Adams Park faithful trudged down the tunnel leaving his team-mates with an uphill struggle, prompting Peter Taylor into making two substitutions to shore up his side.
The stage was then set for Scott Rendell to enhance his growing reputation when he was introduced as a substitute for Ben Strevens on 74 minutes, hoping to build on the hat-trick he scored on Tuesday night.
His strike partner Stuart Beavon had the next chance when he fired over the top from 25 yards but the Blues seemed to be lacking that cutting edge in front of goal which is needed to break down teams who defend in numbers.
That was, of course, until they made the breakthrough with eight minutes remaining, and there was yet more controversy surrounding the goal. The assistant referee flagged for a foul on Stuart Beavon but the referee allowed play to continue, and after Matt Bloomfield was challenged by the keeper, Kevin Betsy rolled the ball home into an empty net.
The Bantams were furious but seemingly the referee had played the advantage in Wycombe's favour, and in fact the visitors had little cause for complaint.
Feeling hard done by, the visitors looked determined to gain revenge and only a first-class save from Nikki Bull at his near post denied Tom Adeyemi's powerful strike in stoppage time.
So Peter Taylor's return to Adams Park ended in defeat but for the Blues, a long overdue home victory was just the tonic for their midweek trophy setback, and sets them up nicely for the trip to second-placed Port Vale next week.
1min: SAVE - Omar Daley flashes a shot across goal which is tipped wide by Nikki Bull.
4mins: SAVE - Ben Strevens forces a save from the keeper from 20 yards.
8mins: CHANCE - Omar Daley races into the area again but can't get his shot on target.
24mins: SAVE - A finger-tip save from Lenny Pidgeley keeps out Stuart Beavon's header.
32mins: YELLOW - Lewis Montrose brings down Omar Daley outside the area and the visitors get a free-kick in a dangerous position.
34mins: SAVE - Nikki Bull claims Lee Hendrie's free-kick at the second attempt.
37mins: CHANCE - Stuart Beavon latches on to Ben Strevens' flick and lifts the ball over the crossbar from 25 yards.
43mins: YELLOW - Dave Syers sees yellow for a nasty collision with Dave Winfield, leaving the Blues' defender needing stitches.
62mins: RED - Tommy Doherty is sent off for shoving Gareth Ainsworth.
69mins: SUBS - Omar Daley and Lee Hendrie come off for Gareth Evans and Leon Osborne.
74mins: SUB - Scott Rendell replaces Ben Strevens.
82mins: GOAL - Kevin Betsy rolls the ball home after the ball breaks to him inside the area.
90mins: SAVE - Nikki Bull denies Tom Adeyemi with a fine save.