Wycombe failed to capitalise on last weekend's excellent win at Bristol Rovers as they suffered a heavy 4-1 defeat to Yeovil Town at Adams Park.
The Glovers sealed just their second away win of the campaign courtesy of a flurry of second half goals after Matt Harrold had cancelled out Dean Bowditch's opener for the visitors.
Andy Welsh, Owain Tudor Jones and Bowditch's second did the damage on a day where only one of the bottom nine teams recorded victories, meaning the Blues are six points adrift of safety with 16 games remaining.
Gary Waddock named the same side that beat Bristol Rovers 3-2 last Saturday. Kevin Betsy remained at right-back and trio Stuart Beavon, Alex Revell and Matt Harrold continued in attack.
And it was Harrold who had the first opportunity of the day, heading wide a Josh Payne cross under pressure from Steven Caulker on four minutes.
Home debutant Alex Revell then forced Glovers keeper Alex McCarthy into a save after cutting in from the left touchline.
But despite enjoying the better of the opening exchanges, Wanderers fell behind on 16 minutes when ex-Wycombe frontman Dean Bowditch side-footed the ball into the top right-hand corner of the net, after Andy Welsh was allowed to ghost into the penalty area and pick out the Glovers' no.14.
The goal forced Waddock's men into their shell and, in truth, were lucky to only being trailing 1-0 on the half hour mark after Welsh somehow scooped the ball over Scott Shearer's bar from two yards out. Bowditch got free down the right and his cross was inch perfect but the Yeovil winger couldn't apply the finishing touch.
However, against the run of play, Wycombe could have been level a minute later. Kevin Betsy surged down the right and slid the ball into the danger area but, with the keeper beaten, Caulker nipped in front of Harrold to deny the ex-Glovers frontman an equaliser.
Defender Chris Westwood then headed wide after a Dean Keates free-kick had caused mayhem in the Glovers box, while at the other end Shearer was on hand to push away a teasing Andy Welsh delivery from the left.
Stuart Beavon then had the ball in Alex McCarthy's net after being put through by John Mousinho but his effort was ruled out for offside.
However, the Adams Park faithful only had to wait another nine minutes before they were celebrating again. Dean Keates' free-kick from the right was met by the head of Harrold and the Blues were back on terms. Harrold rose highest to power his effort past the former Chairboy McCarthy to notch up his ninth goal of the season.
An injury to Adam Hinshelwood disrupted the Blues' flow and within three minutes the visitors were back in front. Bowditch's teasing ball across the box was parried away by Shearer but Welsh was on hand to tap in the rebound.
Wycombe responded briefly through a long-range Josh Payne effort but in fairness Yeovil were the side looking the more likely to score again.
And they did on the hour mark when Norwich loanee Owain Tudur Jones curled the ball round the wall and into the bottom right- hand corner of Shearer's net.
Waddock threw on Jon-Paul Pittman for Stuart Beavon, but five minutes later Wycombe were 4-1 down. Yeovil seized on a loose pass in midfield before the ball was launched down field into the path of Bowditch, who twisted substitute Luke Oliver inside and out before neatly poking the ball home from 12 yards.
Payne brought a good save from the legs of McCarthty and Pittman saw a header cleared off the line from a Keates corner in the closing stages, but Terry Skiverton's side held on for what in the end was a comfortable 4-1 victory.